FPS craters in Trial of the Sekehma

ONLY in my second Trial of the Sekhema runs, around level 65+, there are points where I experience a disastrous drop in video fps. The screen stutters and then locks up for over 2 seconds before resuming, then it happens again. This does not happen anywhere else in PoE2 for me so far.

It might be related to some small critters that swarm around certain rare mobs, but it's very hard to say. It seems to happen in some hourglass trials and some gauntlet trials. It does not happen with any bosses.

All I can do is try to keep spamming attacks with a frozen screen until it stops. As it's a Trial, it's very stressful to lose control and risk the loss of honor with no control.

Does anyone have any idea what might be causing this, and what (if anything) I can do about it?

Obligatory disclosure: I'm running PoE2 using Crossover on a Mac. Yes, that probably has something to do with it, but otherwise fps has been completely fine IMHO.