Zerker slams mitigating damage/tankiness question

Hey all, i'm picturing myself next league to play zerker over jugger/slayer for the first time as i'm really excited to try out some of the zerker nodes. thematically i'm really sold!

My biggest question, having played with slayer/jugg in the past is how do I achieve a high defense sustain and not being "one shot" easily by mechanics. I appreciate all help